Switching between different forms of TRT is generally possible and is often considered when individual needs or tolerability change. In certain cases, combining different forms of therapy may also be appropriate, but this should always be carefully planned on an individual basis.

Oral therapy offers a high degree of flexibility, as the dosage can be adjusted or the treatment paused relatively quickly. Gel therapy can also be easily incorporated into everyday life or used as an alternative, while injections generally require a more gradual transition due to their longer-lasting effects.