The onset of effects can vary depending on the form of treatment. Initial changes such as increased energy, improved mood, or increased libido may occur anywhere from a few hours to several weeks after starting treatment.

Oral therapy can be absorbed relatively quickly and may produce noticeable effects within hours. With gel therapy, the effects tend to develop more gradually and consistently over days to weeks. With injections, the effects begin after administration and then develop and stabilize over a longer period of time.